Structure via PubChem · Public domain (PubChem)
cifenline
Sign in to saveAlso known as cibenzoline
Cibenzoline (or cifenline) is a Class Ia antiarrhythmic.
Chemical data
- Formula
- C18H18N2
- Molecular weight
- 262.3 g/mol
- IUPAC name
- 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
- SMILES
- C1CN=C(N1)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4
- InChIKey
- IPOBOOXFSRWSHL-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 24.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiac arrhythmia
via ChEMBL · EBI
Research
285 papers- Cifenline in the short-term treatment of patients with ventricular premature complexes: a double-blind placebo-controlled study.Journal of cardiovascular pharmacology · 1989
- New antiarrhythmic drugs.Drugs · 1988
- Loss of efficacy during long-term cifenline therapy: development of antiarrhythmic resistance?The Annals of pharmacotherapy · 1993
- The effects of cimetidine and ranitidine on the pharmacokinetics of cifenline.British journal of clinical pharmacology · 1991
- Cifenline succinate and dementia in an elderly NIDDM patient.Diabetes care · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 262.147
Show 3 more facts
- chemical formula
- C₁₈H₁₈N₂
- canonical SMILES
- C1CN=C(N1)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4
- subject has role
- antiarrhythmic agent
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
Cibenzoline (or cifenline) is a Class Ia antiarrhythmic.
Pituxate & Ecipramidil are other gem-diphenyl cyclopropanyl drugs.
Excerpted from Wikipedia’s “cifenline” article, available under the CC BY-SA 4.0 licence.