Structure via PubChem · Public domain (PubChem)
citraconic acid
Sign in to saveAlso known as (2E)-2-METHYLBUT-2-ENEDIOIC ACID, cis-Methylbutenedioic acid, Citraconate, METHYLMALEIC ACID, trans-2-Methyl-2-butenedioic acid, Methylmaleate, (Z)-2-Methyl-2-butenedioate, 2-Methyl-2-butenedioic acid
chemical compound
Chemical data
- Formula
- C5H6O4
- Molecular weight
- 130.1 g/mol
- IUPAC name
- (Z)-2-methylbut-2-enedioic acid
- SMILES
- C/C(=C/C(=O)O)/C(=O)O
- InChIKey
- HNEGQIOMVPPMNR-IHWYPQMZSA-N
- XLogP
- -0.1
- Polar surface area
- 74.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
128 papers- Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein.mSystems · 2025
- Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.Nature metabolism · 2022
- Aconitate decarboxylase (ACOD1) has found a disease.Trends in endocrinology and metabolism: TEM · 2024
- Citraconic acid mitigates radiation-induced intestinal injury by modulating IL-17 signaling to enhance epithelial regeneration.BMC gastroenterology · 2026
- pH-Responsive Charge-Conversion Progelator Peptides.Advanced functional materials · 2021
via PubMed
Wikidata facts
- Subclass of
- dicarboxylic acid
- Mass
- 130.027
Show 6 more facts
- pKa
- 2.42
- chemical formula
- C₅H₆O₄
- melting point
- 90
- isomeric SMILES
- C/C(=C/C(=O)O)/C(=O)O
- canonical SMILES
- CC(=CC(=O)O)C(=O)O
- Commons category
- Citraconic acid
via Wikidata · CC0