Structure via PubChem · Public domain (PubChem)
clofilium
Sign in to saveClofilium is an antiarrhythmic agent.
Chemical data
- Formula
- C21H37ClN+
- Molecular weight
- 339 g/mol
- IUPAC name
- 4-(4-chlorophenyl)butyl-diethyl-heptylazanium
- SMILES
- CCCCCCC[N+](CC)(CC)CCCCC1=CC=C(C=C1)Cl
- InChIKey
- WPSYTTKBGAZSCX-UHFFFAOYSA-N
- XLogP
- 7.2
- Polar surface area
- 0 Ų
- H-bond donors
- 0
- H-bond acceptors
- 0
- Formal charge
- 1
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
228 papers- Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish.Cell death & disease · 2021
- Iberiotoxin and clofilium regulate hyperactivation, acrosome reaction, and ion homeostasis synergistically during human sperm capacitation.Molecular reproduction and development · 2023
- Slo3 K+ channel blocker clofilium extends bull and mouse sperm-fertilizing competence.Reproduction (Cambridge, England) · 2018
- Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.Cancer letters · 1999
- Inhibitory effects of clofilium on membrane currents associated with Ca channels, NMDA receptor channels and Na+, K+-ATPase in cortical neurons.Pharmacology · 2005
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 338.261453
Show 2 more facts
- canonical SMILES
- CCCCCCC[N+](CC)(CC)CCCCC1=CC=C(C=C1)Cl
- chemical formula
- C₂₁H₃₇ClN⁺
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
Clofilium is an antiarrhythmic agent.
Category:Quaternary ammonium compounds Category:Antiarrhythmic agents Category:4-Chlorophenyl compounds
Excerpted from Wikipedia’s “clofilium” article, available under the CC BY-SA 4.0 licence.