CRABP2
Sign in to saveAlso known as CRABP-II, RBP6, cellular retinoic acid binding protein 2
Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene.
Gene data
CRABP2- Name
- cellular retinoic acid binding protein 2
- Type
- protein-coding
- Position
- 156,699,592–156,708,094 (−)
- Aliases
- CRABP-II, RBP6
- Ensembl
- ENSG00000143320
- RefSeq RNA
- NM_001199723.2, NM_001878.4
- RefSeq protein
- NP_001186652.1, NP_001869.1
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
cellular retinoic acid binding protein 2
- Symbol
- CRABP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:156,699,592-156,708,094
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CRABP2 PDB 1blr.png
Show 9 more facts
- HomoloGene ID
- 1415
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1382
- genomic end
- 156675608
- genomic start
- 156669398
- chromosome
- human chromosome 1
- cytogenetic location
- 1q23.1
- expressed in
- vagina
- Commons category
- CRABP2
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Function
- Tissue distribution
- Defects
- Interactions
- References
- External links
- Further reading
Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene.
CRABP2 is structurally similar to CRABP1, but CRABP2 has a lower affinity for retinoic acid (RA). CRABP2 is associated with cells that produce large amounts of retinoic acid and may play a role in mediating the effects of retinoic acid in the cell.
Excerpted from Wikipedia’s “CRABP2” article, available under the CC BY-SA 4.0 licence.