CRAT

Also known as carnitine O-acetyltransferase, CAT1, CAT, NBIA8, Carnitine O-acetyltransferase, carnitine acetyltransferase, carnitine acetylase

protein-coding gene in the species Homo sapiens

Gene data

CRAT

Name: carnitine O-acetyltransferase
Type: protein-coding
Aliases: CAT, CAT1, NBIA8

This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016].

via MyGene.info

Gene · Ensembl

carnitine O-acetyltransferase

Symbol: CRAT
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:129,092,813-129,111,313
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Protein · UniProt

Carnitine O-acetyltransferase

Gene: Crat
Organism: Rattus norvegicus (Rat)
Length: 626 aa
Molecular mass: 70,801 Da
Evidence: 1: Evidence at protein level

Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates

AcetylationAcyltransferaseEndoplasmic reticulumFatty acid metabolismLipid metabolismMembraneMitochondrionMitochondrion inner membrane

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Swiss-Prot (reviewed) · via UniProt