daf-2

Also known as CELE_Y55D5A.5, Insulin-like receptor subunit beta, Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein, Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase;hypothetical protein, Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase

The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 and also Age-1 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”