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daf-2
Sign in to saveAlso known as CELE_Y55D5A.5, Insulin-like receptor subunit beta, Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein, Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase;hypothetical protein, Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 and also Age-1 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”
Gene data
daf-2- Name
- Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
- Type
- protein-coding
- Chromosome
- III
- Position
- 2,994,514–3,040,846 (−)
- Ensembl
- WBGene00000898
- RefSeq RNA
- NM_001312987.4, NM_001312988.3, NM_001312989.3, NM_001312990.3, NM_001312991.3
- RefSeq protein
- NP_001299916.1, NP_001299917.1, NP_001299918.1, NP_001299919.1, NP_001299920.1
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Instance of
- gene
Show 5 more facts
- found in taxon
- Caenorhabditis elegans
- HomoloGene ID
- 30997
- genomic start
- 2995487
- genomic end
- 3040860
- expressed in
- gonad
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Long-lived mutants
- IGF-1 signal pathway
- Role in ''C. elegans'' developmental stages
- Diet’s interaction with the IGF-1 pathway
- See also
- References
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 and also Age-1 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”
==Long-lived mutants==
Excerpted from Wikipedia’s “daf-2” article, available under the CC BY-SA 4.0 licence.