Also known as DCC netrin 1 receptor, CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1, HGPPS2
protein-coding gene in the species Homo sapiens
Gene data
DCC- Name
- DCC netrin 1 receptor
- Type
- protein-coding
- Aliases
- CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].
via MyGene.info
Gene · Ensembl
DCC netrin 1 receptor
- Symbol
- DCC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:52,340,197-53,535,899
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 10 more facts
- HomoloGene ID
- 21081
- genetic association
- alcohol abuse
- genomic start
- 52340197
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1630
- genomic end
- 51057784
- chromosome
- human chromosome 18
- cytogenetic location
- 18q21.2
- different from
- DCC
- expressed in
- caudate nucleus
via Wikidata · CC0