PTK2
Sign in to saveAlso known as FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.
Gene data
PTK2- Name
- protein tyrosine kinase 2
- Type
- protein-coding
- Position
- 140,657,900–141,002,216 (−)
- Aliases
- FADK, FADK 1, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
- Ensembl
- ENSG00000169398
- RefSeq RNA
- NM_001199649.2, NM_001316342.2, NM_001352694.2, NM_001352695.2, NM_001352696.2
- RefSeq protein
- NP_001186578.1, NP_001303271.1, NP_001339623.1, NP_001339624.1, NP_001339625.1
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
~7 min read
Encyclopedic overview
15 sectionsContents
- Function
- Regulation
- Role in apoptosis
- Structure
- C-terminus
- N-terminus
- Catalytic/regulatory domain
- Clinical significance
- As a drug target
- FAK inhibitors
- Interactions
- See also
- References
- Further reading
- External links
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.
== Function == The PTK2 gene encodes a cytosolic protein tyrosine kinase that is found concentrated in the focal adhesions that form among cells attaching to extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases that included PYK2, but lacks significant sequence similarity to kinases from other subfamilies. It also includes a large FERM domain.
Excerpted from Wikipedia’s “PTK2” article, available under the CC BY-SA 4.0 licence.