DDX41
Sign in to saveAlso known as ABS, MPLPF, DEAD-box helicase 41
Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.
Gene data
DDX41- Name
- DEAD-box helicase 41
- Type
- protein-coding
- Aliases
- ABS, MPLPF
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017].
via MyGene.info
Wikidata facts
- Image
- Protein DDX41 PDB 2p6n.png
Show 5 more facts
- HomoloGene ID
- 9431
- exact match
- identifiers.org/ncbigene/51428
- genomic end
- 177516961
- genomic start
- 176938578
- cytogenetic location
- 5q35.3
Sources (7)
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Article
3 sectionsContents
- Function
- References
- Further reading
Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the gene is widely required during post-transcriptional gene expression. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.