DDX41

Also known as ABS, MPLPF, DEAD-box helicase 41

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.

Gene data

DDX41

Name: DEAD-box helicase 41
Type: protein-coding
Position: 177,511,569–177,516,979 (−)
Aliases: ABS, MPLPF
Ensembl: ENSG00000183258
RefSeq RNA: NM_001321732.2, NM_001321830.2, NM_016222.4
RefSeq protein: NP_001308661.1, NP_001308759.1, NP_057306.2

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017].

Pathways

Innate Immune System Immune System STING mediated induction of host immune responses Cytosolic sensors of pathogen-associated DNA Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN mRNA Splicing - Major Pathway mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA Metabolism of RNA

via MyGene.info

Gene · Ensembl

DEAD-box helicase 41

Symbol: DDX41
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:177,511,569-177,516,979
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein DDX41 PDB 2p6n.png

Show 8 more facts

HomoloGene ID: 9431
exact match: identifiers.org/ncbigene/51428
found in taxon: Homo sapiens
genomic end: 177516961
genomic start: 176938578
chromosome: human chromosome 5
cytogenetic location: 5q35.3
expressed in: monocyte

Sources (7)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

Function
References
Further reading

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the gene is widely required during post-transcriptional gene expression. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.

Excerpted from Wikipedia’s “DDX41” article, available under the CC BY-SA 4.0 licence.