STING1
Sign in to saveAlso known as ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING
protein-coding gene in the species Homo sapiens
Gene data
STING1- Name
- stimulator of interferon response cGAMP interactor 1
- Type
- protein-coding
- Position
- 139,475,528–139,482,935 (−)
- Aliases
- ERIS, MITA, MPYS, NET23, SAVI, STING, STING-beta, TMEM173, hMITA, hSTING
- Ensembl
- ENSG00000288243
- RefSeq RNA
- NM_001301738.2, NM_001367258.1, NM_198282.4
- RefSeq protein
- NP_001288667.1, NP_001354187.1, NP_938023.1
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
stimulator of interferon response cGAMP interactor 1
- Symbol
- STING1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HG1395_PATCH:65,328-72,730
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- STING 4EMU.jpg
Show 8 more facts
- HomoloGene ID
- 18868
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/340061
- genomic end
- 138862520
- genomic start
- 139475533
- chromosome
- human chromosome 5
- cytogenetic location
- 5q31.2
- expressed in
- ascending aorta
Sources (7)
via Wikidata · CC0