DEFA3

Also known as DEF3, HNP-3, HNP3, HP-3, HP3, defensin alpha 3

thumb|300 px|Defensin 3, dimer, Human.

Gene data

DEFA3

Name: defensin alpha 3
Type: protein-coding
Position: 7,015,869–7,018,359 (−)
Aliases: DEF3, HNP-3, HNP3, HP-3, HP3
Ensembl: ENSG00000239839
RefSeq RNA: NM_005217.4, XM_011534741.3, XM_054332234.1, XM_054359869.1
RefSeq protein: NP_005208.1, XP_011533043.1, XP_054188209.1, XP_054215844.1

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014].

Gene Ontology

Biological process

innate immune response in mucosa defense response antibacterial humoral response antibacterial humoral response estrogen receptor signaling pathway killing of cells of another organism innate immune response defense response to Gram-negative bacterium

Molecular function

protein homodimerization activity pore-forming activity

Cellular component

extracellular region extracellular region extracellular region extracellular region extracellular region Golgi lumen Golgi lumen azurophil granule lumen

Pathways

NOD-like receptor signaling pathway - Homo sapiens (human)Staphylococcus aureus infection - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Defensins Alpha-defensins Innate Immune System Immune System Antimicrobial peptides

via MyGene.info

Gene · Ensembl

defensin alpha 3

Symbol: DEFA3
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:7,015,868-7,018,359
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein DEFA3 PDB 1dfn.png

Show 5 more facts

HomoloGene ID: 128756
exact match: identifiers.org/ncbigene/1668
genomic end: 7018297
genomic start: 6873391
cytogenetic location: 8p23.1

Sources (4)

via Wikidata · CC0

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Article

3 sections

Contents

Function
References
Further reading

thumb|300 px|Defensin 3, dimer, Human.

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene. Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.