DEFA6

Also known as DEF6, HD-6, defensin alpha 6

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene. DEFA6 is expressed in the Paneth cells of the ileum.

Gene data

DEFA6

Name: defensin alpha 6
Type: protein-coding
Position: 6,924,697–6,926,076 (−)
Aliases: DEF6, HD-6
Ensembl: ENSG00000285136
RefSeq RNA: NM_001926.4
RefSeq protein: NP_001917.1

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014].

Gene Ontology

Biological process

defense response antibacterial humoral response killing of cells of another organism innate immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium disruption of plasma membrane integrity in another organism antimicrobial humoral immune response mediated by antimicrobial peptide

Molecular function

protein binding protein homodimerization activity pore-forming activity

Cellular component

extracellular region extracellular region extracellular region extracellular region Golgi lumen Golgi lumen transport vesicle

Pathways

NOD-like receptor signaling pathway - Homo sapiens (human)Staphylococcus aureus infection - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Defensins Alpha-defensins Innate Immune System Immune System Antimicrobial peptides

via MyGene.info

Gene · Ensembl

defensin alpha 6

Symbol: DEFA6
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:6,924,697-6,926,076
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PDB 1zmq EBI.png

Show 8 more facts

exact match: identifiers.org/ncbigene/1671
HomoloGene ID: 130499
found in taxon: Homo sapiens
genomic end: 6783598
genomic start: 6924697
chromosome: human chromosome 8
cytogenetic location: 8p23.1
expressed in: gastric mucosa

Sources (4)

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Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene. DEFA6 is expressed in the Paneth cells of the ileum.

== Function ==

Excerpted from Wikipedia’s “DEFA6” article, available under the CC BY-SA 4.0 licence.

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