In biology, depolarization or hypopolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell compared to the outside. Depolarization is essential to the function of many cells, communication between cells, and the overall physiology of an organism. thumb|right|Action potential in a [[neuron, showing depolarization, in which the cell's internal charge becomes less negative (more positive), and repolarization, where the internal charge returns to a more negative value.]] Most cells in higher o
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It sits within the topics Cellular neuroscience, Electrochemistry and Electrophysiology.
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