DERL2
Sign in to saveAlso known as F-LAN-1, F-LANa, FLANa, CGI-101, DERtrin-2, derlin 2, derlin-2
Derlin-2 is a protein that in humans is encoded by the DERL2 gene.
Gene data
DERL2- Name
- derlin 2
- Type
- protein-coding
- Position
- 5,471,254–5,486,817 (−)
- Aliases
- CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa, derlin-2
- Ensembl
- ENSG00000072849
- RefSeq RNA
- NM_001304777.2, NM_001304779.2, NM_016041.5, NR_130905.2, NR_130906.2
- RefSeq protein
- NP_001291706.1, NP_001291708.1, NP_057125.2, XP_047292141.1, XP_047292142.1
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008].
Gene Ontology
Biological process
ubiquitin-dependent protein catabolic processpositive regulation of cell population proliferationpositive regulation of cell growthendoplasmic reticulum unfolded protein responseendoplasmic reticulum unfolded protein responseendoplasmic reticulum unfolded protein responseretrograde protein transport, ER to cytosolERAD pathway
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
derlin 2
- Symbol
- DERL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:5,471,254-5,486,817
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 9356
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51009
- genomic end
- 5390131
- genomic start
- 5471254
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.2
- expressed in
- granulocyte
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Derlin-2 is a protein that in humans is encoded by the DERL2 gene.
== See also == Derlin-1 Derlin-3
Excerpted from Wikipedia’s “DERL2” article, available under the CC BY-SA 4.0 licence.