dihydroorotase
Sign in to saveAlso known as carbamoylaspartic dehydrase, (S)-dihydroorotate amidohydrolase, dihydroorotate hydrolase, DHOase
Dihydroorotase (, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines. It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.
Research
649 papers- Crystal structure of Methanococcus jannaschii dihydroorotase.Proteins · 2023
- Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus.Cell communication and signaling : CCS · 2024
- The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting.International journal of molecular sciences · 2025
- Functional analyses of Toxoplasma gondii dihydroorotase reveal a promising anti-parasitic target.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
- Pyrimidine biosynthesis.The American journal of clinical nutrition · 1979
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Wikidata facts
- Subclass of
- amidohydrolases
- Image
- 4by3.jpg
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- EC enzyme number
- 3.5.2.3
- Commons category
- Dihydroorotase
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Encyclopedic overview
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Dihydroorotase (, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines. It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.
== See also == Pyrimidine biosynthesis
Excerpted from Wikipedia’s “dihydroorotase” article, available under the CC BY-SA 4.0 licence.