duvoglustat
Sign in to saveAlso known as AT-2220, S-GI, 1,5-Deoxy-1,5-imino-D-mannitol, Moranoline, 1,5-Dideoxy-1,5-imino-D-glucitol, 1-Deoxymannojirimycin, DNJ, 1,5-dideoxy-1,5-imino-D-glucitol
1-Deoxynojirimycin (DNJ or 1-DNJ), also called duvoglustat or moranolin, is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillus species.
Research
1,901 papers- 1-Deoxynojirimycin promotes cardiac function and rescues mitochondrial cristae in mitochondrial hypertrophic cardiomyopathy.The Journal of clinical investigation · 2023
- Duvoglustat HCl Increases Systemic and Tissue Exposure of Active Acid α-Glucosidase in Pompe Patients Co-administered with Alglucosidase α.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
- Arimoclomol: First Approval.Drugs · 2025
- Safety and efficacy of migalastat in adolescent patients with Fabry disease: Results from ASPIRE, a phase 3b, open-label, single-arm, 12-month clinical trial, and its open-label extension.Molecular genetics and metabolism · 2025
- Cipaglucosidase Alfa: First Approval.Drugs · 2023
via PubMed
~2 min read
Encyclopedic overview
4 sectionsContents
- Biosynthesis
- Pathway variations
- See also
- References
1-Deoxynojirimycin (DNJ or 1-DNJ), also called duvoglustat or moranolin, is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillus species.
== Biosynthesis == 1-Deoxynojirimycin is a polyhydroxylated piperidine alkaloid produced from D-Glucose in various plants, such as Commelina communis, and in the Streptomyces and Bacillus bacteria. High quantities of this iminosugar are produced in Bacillus subtilis, a process initiated by a TYB gene cluster composed of gabT1 (aminotransferase), yktc1 (phosphatase), and gutB1 (oxidoreductase).
Excerpted from Wikipedia’s “duvoglustat” article, available under the CC BY-SA 4.0 licence.