EF-5
Sign in to saveAlso known as EF5, 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
EF5 is a nitroimidazole derivative used in oncology research. Due to its similarity in chemical structure to etanidazole, EF5 binds in cells displaying hypoxia.
Research
143 papers- Pneumonia cases following an EF-5 tornado.American journal of infection control · 2015
- Large variations in indirect N(2)O emission factors (EF(5)) from coastal aquaculture systems in China from plot to regional scales.Water research · 2021
- Intermuscle differences in activation.Muscle & nerve · 2002
- Left Bundle Branch Block as a Risk Factor for Heart Failure.JAMA network open · 2025
- Change in Left Ventricular Ejection Fraction With Coronary Artery Revascularization and Subsequent Risk for Adverse Cardiovascular Outcomes.Circulation. Cardiovascular interventions · 2022
via PubMed
Wikidata facts
- Mass
- 302.044
Show 2 more facts
- chemical formula
- C₈H₇F₅N₄O₃
- canonical SMILES
- C1=CN(C(=N1)[N+](=O)[O-])CC(=O)NCC(C(F)(F)F)(F)F
Sources (2)
via Wikidata · CC0
~1 min read
Article
1 sectionsContents
- References
EF5 is a nitroimidazole derivative used in oncology research. Due to its similarity in chemical structure to etanidazole, EF5 binds in cells displaying hypoxia.
Non-labeled EF5 has been extensively used in immunohistochemical studies for several years and its hypoxia specificity has been comprehensively evaluated The 18F-radiolabeled derivative of EF5 is being studied for its possibility to be used in positron emission tomography (PET) to detect low levels of oxygen in brain tumors and several other malignant tumors. This can help show how a tumor will respond to treatment.