Epoxomicin
Sign in to saveEpoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. It was originally discovered in 1992. Injected, it can induce Parkinson's-like symptoms in rats.
Research
415 papers- Heterologous Expression of Epoxomicin in Escherichia coli.ACS synthetic biology · 2024
- From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes.Natural product reports · 2013
- Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells.Antioxidants (Basel, Switzerland) · 2022
- Epoxomicin Sensitizes Resistant Osteosarcoma Cells to TRAIL Induced Apoptosis.Anti-cancer agents in medicinal chemistry · 2015
- Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.Bioorganic & medicinal chemistry letters · 2008
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Encyclopedic overview
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Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. It was originally discovered in 1992. Injected, it can induce Parkinson's-like symptoms in rats.
Derivatives of epoxomicin include carfilzomib.
Excerpted from Wikipedia’s “Epoxomicin” article, available under the CC BY-SA 4.0 licence.