ERCC1
Sign in to saveDNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.
Article
18 sectionsContents
- Gene
- Protein
- Structure-specific nuclease
- Nucleotide excision repair
- DNA double-strand break repair
- DNA interstrand crosslink repair
- Clinical significance
- Cerebro-oculo-facio-skeletal syndrome
- Cockayne syndrome
- Relevance in chemotherapy
- Deficiency in cancer
- Accelerated aging
- Spermatogenesis and oogenesis
- Macular degeneration
- Notes
- References
- Further reading
- External links
DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.
Many aspects of these two gene products are described together here because they are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of "crosslink" damage that harmfully links the two DNA strands.