Also known as CF2R, HTR, PAR-1, PAR1, TR, Coagulation factor II receptor, coagulation factor II thrombin receptor
protein-coding gene in the species Homo sapiens
Gene data
F2R- Name
- coagulation factor II thrombin receptor
- Type
- protein-coding
- Position
- 76,716,126–76,735,770 (+)
- Aliases
- CF2R, HTR, PAR-1, PAR1, TR
- Ensembl
- ENSG00000181104
- RefSeq RNA
- NM_001311313.2, NM_001992.5
- RefSeq protein
- NP_001298242.1, NP_001983.2
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology
Biological process
connective tissue replacement involved in inflammatory response wound healingnegative regulation of glomerular filtrationinflammatory responseG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathwayphospholipase C-activating G protein-coupled receptor signaling pathwayphospholipase C-activating G protein-coupled receptor signaling pathwayphospholipase C-activating G protein-coupled receptor signaling pathway
Molecular function
Pathways
Rap1 signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Complement and coagulation cascades - Homo sapiens (human)Platelet activation - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
coagulation factor II thrombin receptor
- Symbol
- F2R
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:76,715,820-76,735,770
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- PDB 1nrn EBI.jpg
Show 6 more facts
- HomoloGene ID
- 1510
- exact match
- identifiers.org/ncbigene/2149
- genomic end
- 76735770
- genomic start
- 76716126
- cytogenetic location
- 5q13.3
- Commons category
- Coagulation factor II receptor
Sources (4)
via Wikidata · CC0