FOLR1
Sign in to saveAlso known as FBP, FOLR, Folate receptor 1, folate receptor 1 (adult), folate receptor alpha, FRalpha, NCFTD
protein-coding gene in the species Homo sapiens
Gene data
FOLR1- Name
- folate receptor alpha
- Type
- protein-coding
- Position
- 72,189,529–72,199,329 (+)
- Aliases
- FBP, FOLR, FR-alpha, FRalpha, NCFTD
- Ensembl
- ENSG00000110195
- RefSeq RNA
- NM_000802.3, NM_016724.3, NM_016725.3, NM_016729.3, NM_016730.1
- RefSeq protein
- NP_000793.1, NP_057936.1, NP_057937.1, NP_057941.1
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
folate receptor alpha
- Symbol
- FOLR1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:72,189,529-72,199,329
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 7322
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2348
- chromosome
- human chromosome 11
- genomic start
- 71900602
- genomic end
- 72196323
- cytogenetic location
- 11q13.4
- genetic association
- cerebral folate receptor alpha deficiency
- Commons category
- Folate receptor alpha
Sources (7)
via Wikidata · CC0