FBXW2

Name

F-box and WD repeat domain containing 2

Type

protein-coding

Position

120,751,978–120,793,438 (−)

Aliases

FBW2, Fwd2, Md6

Ensembl

ENSG00000119402

RefSeq RNA

NM_001375888.1, NM_001375889.1, NM_001375890.1, NM_012164.4, XM_006717049.4

RefSeq protein

NP_001362817.1, NP_001362818.1, NP_001362819.1, NP_036296.2, XP_006717112.1

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

F-box and WD repeat domain containing 2

Symbol

FBXW2

Biotype

Protein coding

Organism

Homo sapiens

Location

9:120,751,978-120,793,438

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0