SKP1

Also known as EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, S-phase kinase associated protein 1

protein-coding gene in the species Homo sapiens

Gene data

SKP1

Name: S-phase kinase associated protein 1
Type: protein-coding
Position: 134,145,693–134,177,911 (−)
Aliases: EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A
Ensembl: ENSG00000113558
RefSeq RNA: NM_006930.4, NM_170679.3
RefSeq protein: NP_008861.2, NP_733779.1

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008].