filaggrin
Sign in to saveAlso known as epidermal filaggrin, FLG
Filaggrin (filament aggregating protein; FLG) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. In cetaceans and sirenians, the FLG family has lost its function, with the curious exception of manatees in the latter clade: manatee
Protein · UniProt
Filaggrin
- Gene
- FLG
- Organism
- Homo sapiens (Human)
- Length
- 4,061 aa
- Molecular mass
- 435,170 Da
- Evidence
- 1: Evidence at protein level
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
7 registered- NACOMPLETEDShort-term Topical Application to Prevent Atopic DermatitisUniversity College Cork · NCT03871998
- ENROLLING_BY_INVITATIONInvestigation of Filaggrin Gene Mutations Among Latinx Patients With Atopic DermatitisUniversity of Pennsylvania · NCT06464133
- ACTIVE_NOT_RECRUITINGThe Role of Filaggrin Mutations and Sensitization Pathways in Allergic Rhinitis and Peanut AllergyDr. Anne Ellis · NCT02745418
- ACTIVE_NOT_RECRUITINGDefining the Skin and Blood Biomarkers of Pediatric Atopic DermatitisNorthwestern University · NCT01782703
- NACOMPLETEDGenetic Screening for Filaggrin Mutation in Atopic Dermatitis and Ichthyosis Vulgaris in the African American PopulationNorthwestern University · NCT01016106
- COMPLETEDThe Role of Filaggrin and FADS Genes on the Concentrations of PUFA Towards Its Effect on Atopic Dermatitis in InfantsIndonesia University · NCT02401178
~4 min read
Encyclopedic overview
7 sectionsContents
- Profilaggrin
- Structure
- Function
- Clinical significance
- See also
- References
- External links
Filaggrin (filament aggregating protein; FLG) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. In cetaceans and sirenians, the FLG family has lost its function, with the curious exception of manatees in the latter clade: manatees still retain some functional FLG genes.
== Profilaggrin ==
Excerpted from Wikipedia’s “filaggrin” article, available under the CC BY-SA 4.0 licence.