Coagulation factor II, thrombin
Sign in to savethumb|360px|alt=Schematic diagram of the blood coagulation and protein C pathways. In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa V to Va, fibrinogen to fibrin. In addition, thrombin promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin also cross over into the protein C pathway by converting protein C into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates PAR-1 and EPCR.|Role of thrombin in the blood coagulation cascade
Article
16 sectionsContents
- History
- Physiology
- Synthesis
- Mechanism of action
- Negative feedback
- Structure
- Gene
- Role in disease
- Applications
- Research tool
- Medicine and surgery
- Food production
- See also
- References
- Further reading
- External links
thumb|360px|alt=Schematic diagram of the blood coagulation and protein C pathways. In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa V to Va, fibrinogen to fibrin. In addition, thrombin promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin also cross over into the protein C pathway by converting protein C into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates PAR-1 and EPCR.|Role of thrombin in the blood coagulation cascade
Thrombin (factor IIa, ) is a serine protease that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions.