FLRT2

Name

fibronectin leucine rich transmembrane protein 2

Type

protein-coding

Position

85,530,017–85,654,428 (+)

Ensembl

ENSG00000185070

RefSeq RNA

NM_001346143.2, NM_001346144.2, NM_001346145.2, NM_001346146.2, NM_013231.6

RefSeq protein

NP_001333072.1, NP_001333073.1, NP_001333074.1, NP_001333075.1, NP_037363.1

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].

via MyGene.info

Gene · Ensembl

fibronectin leucine rich transmembrane protein 2

Symbol

FLRT2

Biotype

Protein coding

Organism

Homo sapiens

Location

14:85,530,017-85,654,428

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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