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GeneQ17928884· pop 5· linked from 331 articles

FMO5

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Also known as flavin containing monooxygenase 5, flavin containing dimethylaniline monoxygenase 5, hBVMO1

Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme in humans encoded by the FMO5 gene.

Gene data

FMO5
Name
flavin containing dimethylaniline monoxygenase 5
Type
protein-coding
Position
147,175,351–147,243,050 (−)
Aliases
hBVMO1
Ensembl
ENSG00000131781
RefSeq RNA
NM_001144829.3, NM_001144830.3, NM_001461.4, XM_005272946.6, XM_005272947.6
RefSeq protein
NP_001138301.1, NP_001138302.1, NP_001452.2, XP_005273003.1, XP_005273004.1

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009].

Gene Ontology

Pathways

Drug metabolism - cytochrome P450 - Homo sapiens (human)1q21.1 copy number variation syndromeCatalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs)Metapathway biotransformation Phase I and II

via MyGene.info

Gene · Ensembl

flavin containing dimethylaniline monoxygenase 5

Symbol
FMO5
Biotype
Protein coding
Organism
Homo sapiens
Location
1:147,175,351-147,243,050
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections
Contents
  • Related gene problems
  • References
  • Further reading

Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme in humans encoded by the FMO5 gene.

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Excerpted from Wikipedia’s “FMO5” article, available under the CC BY-SA 4.0 licence.

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