CYP3A7
Sign in to saveAlso known as CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7, P450HLp2
CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. The gene location is 7q22.1.
Gene data
CYP3A7- Name
- cytochrome P450 family 3 subfamily A member 7
- Type
- protein-coding
- Aliases
- CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2
This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015].
via MyGene.info
Gene · Ensembl
cytochrome P450 family 3 subfamily A member 7
- Symbol
- CYP3A7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:99,704,105-99,735,196
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 133564
- exact match
- identifiers.org/ncbigene/1551
- genomic end
- 99332819
- genomic start
- 99705036
- cytogenetic location
- 7q22.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Notable alleles
- References
- External links
CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. The gene location is 7q22.1.
The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.