FOLR2
Sign in to saveAlso known as BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.
Gene data
FOLR2- Name
- folate receptor beta
- Type
- protein-coding
- Aliases
- BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, FRbeta
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 627
- exact match
- identifiers.org/ncbigene/2350
- genomic end
- 71932994
- genomic start
- 71927645
- cytogenetic location
- 11q13.4
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Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.
The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence identity with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.