forodesine
Sign in to saveAlso known as BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, immucillin-H, (2R,3R,4S,5S)-2-(hydroxymethyl)-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol, (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol
Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 266.102
Show 4 more facts
- chemical formula
- C₁₁H₁₄N₄O₄
- isomeric SMILES
- C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
- canonical SMILES
- C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
- Commons category
- Immucillin H
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Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).
Forodesine was originally discovered by Vern Schramm's laboratory at the Albert Einstein College of Medicine in New York and Industrial Research Limited in New Zealand.
Excerpted from Wikipedia’s “forodesine” article, available under the CC BY-SA 4.0 licence.