FYB1
Sign in to saveFYN binding protein (FYB-120/130), also known as FYB, ADAP (Adhesion and degranulation-promoting adapter protein), and SLAP-130 (SLP-76-associated phosphoprotein) is a protein that is encoded by the FYB gene in humans. The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.
Gene data
FYB1- Name
- FYN binding protein 1
- Type
- protein-coding
- Position
- 39,105,252–39,274,528 (−)
- Aliases
- ADAP, FYB, PRO0823, SLAP-130, SLAP130, THC3
- Ensembl
- ENSG00000082074
- RefSeq RNA
- NM_001243093.2, NM_001349333.2, NM_001445394.1, NM_001465.6, NM_018594.2
- RefSeq protein
- NP_001230022.1, NP_001336262.1, NP_001432323.1, NP_001456.3, NP_061064.2
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
FYN binding protein 1
- Symbol
- FYB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:39,105,251-39,274,528
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FYB PDB 1ri9.png
Show 5 more facts
- HomoloGene ID
- 22664
- exact match
- identifiers.org/ncbigene/2533
- genomic start
- 39105252
- genomic end
- 39274630
- cytogenetic location
- 5p13.1
Sources (3)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Structure
- Function
- References
- Further reading
FYN binding protein (FYB-120/130), also known as FYB, ADAP (Adhesion and degranulation-promoting adapter protein), and SLAP-130 (SLP-76-associated phosphoprotein) is a protein that is encoded by the FYB gene in humans. The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.
== Structure == Two isoforms of FYB with different lengths of 120 and 130 kDa (FYB-120 and FYB-130) exist. The 130kDa version has an extra insertion of 46 amino acids and is preferentially expressed in peripheral T cells. The FYB protein has a variety of binding domains: a non-structured N-terminal region, a proline-rich region, two SH3 domains, a FPPP-motif which binds the ENA/VASP protein family, and other tyrosine-based signaling motifs.