Structure via PubChem · Public domain (PubChem)
gabexate
Sign in to saveGabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis.
Chemical data
- Formula
- C16H23N3O4
- Molecular weight
- 321.37 g/mol
- IUPAC name
- ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate
- SMILES
- CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
- InChIKey
- YKGYIDJEEQRWQH-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 117 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- liver disease
via ChEMBL · EBI
Research
928 papers- Efficacy of gabexate mesilate in preventing post endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis of randomized clinical trials.Journal of the Formosan Medical Association = Taiwan yi zhi · 2021
- Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials.BMC gastroenterology · 2007
- Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial.Gastrointestinal endoscopy · 2002
- Use of gabexate mesylate in Italian hospitals: a multicentre observational study.Journal of clinical pharmacy and therapeutics · 2003
- Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials.Journal of gastroenterology and hepatology · 2007
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 321.169
- Has use
- medication
Show 2 more facts
- chemical formula
- C₁₆H₂₃N₃O₄
- canonical SMILES
- CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis.
== References ==
Excerpted from Wikipedia’s “gabexate” article, available under the CC BY-SA 4.0 licence.