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GeneQ18029722· pop 6· linked from 9 articles

GADD45B

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Also known as GADD45BETA, MYD118, growth arrest and DNA damage inducible beta

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene.

Gene data

GADD45B
Name
growth arrest and DNA damage inducible beta
Type
protein-coding
Position
2,476,122–2,478,805 (+)
Aliases
GADD45BETA, MYD118
Ensembl
ENSG00000099860
RefSeq RNA
NM_015675.4
RefSeq protein
NP_056490.2

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008].

Gene Ontology

Molecular function

protein binding

Pathways

MAPK signaling pathway - Homo sapiens (human)NF-kappa B signaling pathway - Homo sapiens (human)FoxO signaling pathway - Homo sapiens (human)Cell cycle - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

growth arrest and DNA damage inducible beta

Symbol
GADD45B
Biotype
Protein coding
Organism
Homo sapiens
Location
19:2,476,122-2,478,805
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
exact match
identifiers.org/ncbigene/4616
HomoloGene ID
7433
found in taxon
Homo sapiens
genomic end
2478257
genomic start
2476120
chromosome
human chromosome 19
cytogenetic location
19p13.3
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Interactions
  • See also
  • References
  • Further reading

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene.

== Function ==

Excerpted from Wikipedia’s “GADD45B” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0