Structure via PubChem · Public domain (PubChem)
gestrinone
Sign in to saveAlso known as Tridomose, 13-Ethyl-17-hydroxy-18,19-Dinor-17a-pregna-4,9,11-trien-20-yn-3-one, Gestrinona, Dimetriose, Ethylnorgestrienone, (17a)-13-ethyl-17-hydroxy-18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-Ethyl-17a-ethynyl-17b-hydroxygona-4,9,11-trien-3-one, Gestrigone
farmaco
Chemical data
- Formula
- C21H24O2
- Molecular weight
- 308.4 g/mol
- IUPAC name
- (8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- SMILES
- CC[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(C#C)O
- InChIKey
- BJJXHLWLUDYTGC-ANULTFPQSA-N
- XLogP
- 2.2
- Polar surface area
- 37.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
299 papers- Effects, Doses, and Applicability of Gestrinone in Estrogen-Dependent Conditions and Post-Menopausal Women.Pharmaceuticals (Basel, Switzerland) · 2024
- Safety Profile of Gestrinone: A Systematic Review.Pharmaceutics · 2025
- Evaluation of safety and effectiveness of gestrinone in the treatment of endometriosis: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2023
- Lack of Scientific Evidence for the Use of Gestrinone in the Treatment of Lipedema: A Systematic Review.Cureus · 2025
- Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer.Translational research : the journal of laboratory and clinical medicine · 2022
via PubMed
Wikidata facts
- Mass
- 308.178
Show 6 more facts
- defined daily dose
- 0.7
- chemical formula
- C₂₁H₂₄O₂
- canonical SMILES
- CCC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(C#C)O
- isomeric SMILES
- CC[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(C#C)O
- subject has role
- oral contraceptive
- Commons category
- Gestrinone
Sources (3)
via Wikidata · CC0
Article · Italiano
Il Gestrinone è un ormone steroideo di sintesi che ha attività anti-progestinica e lievemente androgena. Gestrinone è stato approvato per l'uso in diversi paesi, ma non negli Stati Uniti; in Italia, pur essendo stato approvato, per problemi di sito produttivo vi sono difficoltà di reperimento. Per gli effetti anabolizzanti, il suo impiego nelle manifestazioni sportive è stato vietato dal CIO (Comitato Olimpico Internazionale).
Abstract from DBpedia / Wikipedia · CC BY-SA