GNL3
Sign in to saveAlso known as C77032, E2IG3, NNP47, NS, G protein nucleolar 3
Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. It is found within the nucleolus that binds p53. Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. It is a marker for many stem cells and cancer cells.
Gene data
GNL3- Name
- G protein nucleolar 3
- Type
- protein-coding
- Aliases
- C77032, E2IG3, NNP47, NS, Nug1
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
via MyGene.info
Wikidata facts
Show 3 more facts
- HomoloGene ID
- 56670
- exact match
- identifiers.org/ncbigene/26354
- cytogenetic location
- 3p21.1
Sources (3)
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Article
3 sectionsContents
- Interactions
- References
- Further reading
Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. It is found within the nucleolus that binds p53. Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. It is a marker for many stem cells and cancer cells.
== Interactions == GNL3 has been shown to interact with Mdm2 and P53.