tumor protein p53
Also known as Tumor suppressor p53, transformation-related protein 53, tumor supressor p53, TP53, mutant tumor protein 53, p53 tumor suppressor, antigen NY-CO-13, phosphoprotein p53
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
Research
14,557 papers- Mutational processes shape the landscape of TP53 mutations in human cancer.Nature genetics · 2018
- Targeting a neoantigen derived from a common TP53 mutation.Science (New York, N.Y.) · 2021
- Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.Nature medicine · 2020
- Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.Journal of experimental & clinical cancer research : CR · 2023
- Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions.Molecular diagnosis & therapy · 2013
via PubMed
Wikidata facts
- Image
- P53.png
Sources (6)
Article
27 sectionsContents
- Gene
- Structure
- Tetramerization
- Isoforms
- Function
- DNA damage and repair
- Stem cells
- Other
- Regulation
- Basal regulation
- Activation by cellular stress
- Stress-responsive kinases
- Deubiquitination
- Post-translational modifications and cofactors
- Dynamics
- Epigenetics
- Role in disease
- Mutations
- Codon 72 variations
- Therapeutic reactivation and gene therapy
- Diagnostic and prognostic significance
- Discovery
- Interactions
- See also
- Notes
- References
- External links
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. In addition to the full-length protein, the human TP53 gene encodes at least 12 protein isoforms.