gp41
Sign in to saveAlso known as glycoprotein 41, HIV Envelope Protein gp41
Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells. As a result of its importance in host cell infection, it has also received much attention as a potential target for HIV vaccines.
Research
5,271 papers- Neutralizing Antibodies Targeting HIV-1 gp41.Viruses · 2020
- HIV-1 gp41: mediator of fusion and target for inhibition.AIDS reviews · 2003
- Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.PLoS pathogens · 2020
- HIV-1 gp41 as a target for viral entry inhibition.Current pharmaceutical design · 2004
- HIV-1 gp41 and type I interferon: sequence homology and biological as well as clinical implications.Immunologic research · 2000
via PubMed
Clinical Trials
3 registered- PHASE1COMPLETEDEvaluating the Safety and Immunogenicity of an HIV-1 gp41 MPER-656 Liposome Vaccine in Healthy, HIV-uninfected Adult ParticipantsNational Institute of Allergy and Infectious Diseases (NIAID) · NCT03934541
- PHASE1/PHASE2COMPLETEDA Dose Response and Safety Study of Procaine HCl in HIV-Infected PatientsSamaritan Pharmaceuticals, Inc · NCT00299338
- NACOMPLETED3Sm Challenge Model ProtocolImperial College London · NCT04753892
~7 min read
Encyclopedic overview
6 sectionsContents
- Gene and post-translational modifications
- Structure
- Function
- As a drug target
- References
- External links
Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells. As a result of its importance in host cell infection, it has also received much attention as a potential target for HIV vaccines.
== Gene and post-translational modifications ==
Excerpted from Wikipedia’s “gp41” article, available under the CC BY-SA 4.0 licence.