English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18033268· pop 5· linked from 5 articles

GPAA1

Sign in to save

Also known as GAA1, hGAA1, glycosylphosphatidylinositol anchor attachment 1, GPIBD15

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

Gene data

GPAA1

Name: glycosylphosphatidylinositol anchor attachment 1
Type: protein-coding
Position: 144,082,337–144,093,149 (+)
Aliases: GAA1, GPIBD15, hGAA1
Ensembl: ENSG00000197858
RefSeq RNA: NM_003801.4
RefSeq protein: NP_003792.1

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

GPI anchor biosynthetic process protein retention in ER lumen attachment of GPI anchor to protein attachment of GPI anchor to protein attachment of GPI anchor to protein attachment of GPI anchor to protein attachment of GPI anchor to protein GPI anchored protein biosynthesis

Molecular function

protein binding GPI anchor binding GPI anchor binding

Cellular component

endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane membrane membrane GPI-anchor transamidase complex

Pathways

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human)Attachment of GPI anchor to uPAR Post-translational modification: synthesis of GPI-anchored proteins Metabolism of proteins Post-translational protein modification

via MyGene.info

Gene · Ensembl

glycosylphosphatidylinositol anchor attachment 1

Symbol: GPAA1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:144,082,337-144,093,149
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 37852
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8733
chromosome: human chromosome 8
genomic start: 145137493
genomic end: 145141119
cytogenetic location: 8q24.3
expressed in: body of stomach

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.

Excerpted from Wikipedia’s “GPAA1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0