GPSM2

Name

G protein signaling modulator 2

Type

protein-coding

Position

108,875,350–108,934,545 (+)

Aliases

CMCS, DFNB82, LGN, PINS

Ensembl

ENSG00000121957

RefSeq RNA

NM_001321038.2, NM_001321039.3, NM_013296.5, XM_006710589.4, XM_011541302.4

RefSeq protein

NP_001307967.1, NP_001307968.1, NP_037428.3, XP_006710652.1, XP_011539604.1

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

via MyGene.info

Wikidata facts

via Wikidata · CC0