NUMA1
Sign in to saveAlso known as NUMA, NMP-22, nuclear mitotic apparatus protein 1
protein-coding gene in the species Homo sapiens
Gene data
NUMA1- Name
- nuclear mitotic apparatus protein 1
- Type
- protein-coding
- Position
- 72,002,860–72,080,693 (−)
- Aliases
- NMP-22, NUMA
- Ensembl
- ENSG00000137497
- RefSeq RNA
- NM_001286561.2, NM_006185.4, NR_104476.2, XM_006718564.3, XM_011545054.3
- RefSeq protein
- NP_001273490.1, NP_006176.2, XP_006718627.1, XP_011543356.1, XP_011543357.1
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
Gene Ontology
Biological process
establishment of mitotic spindle orientationestablishment of mitotic spindle orientationestablishment of mitotic spindle orientationestablishment of mitotic spindle orientationestablishment of mitotic spindle orientationestablishment of mitotic spindle orientationmicrotubule bundle formationnucleus organization
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nuclear mitotic apparatus protein 1
- Symbol
- NUMA1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:72,002,860-72,080,693
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI