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Grey's Anatomy is an American medical drama television series focusing on the personal and professional lives of surgical interns, residents, and attendings at the fictional Seattle Grace Hospital. The series premiered on March 27, 2005, on ABC as a mid-season replacement and has been renewed annually for two decades. Its title is a mixture of the protagonist's surname and the name of the classic human anatomy textbook Gray's Anatomy. Writer Shonda Rhimes developed the pilot and served as showrunner, head writer, and executive producer until stepping down in 2015. Set in Seattle, Washington, the series is filmed primarily in Los Angeles, California, and Vancouver, British Columbia.

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Grey's Anatomy is a medical drama that follows the personal and professional lives of surgeons at a fictional Seattle hospital, starting with their training as interns. Since its premiere in 2005, the show has become a long-running series on ABC, created and initially overseen by Shonda Rhimes, and is named after both its main character's surname and the famous medical textbook Gray's Anatomy.

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