Grey's Anatomy

Grey's Anatomy is an American medical drama television series focusing on the personal and professional lives of surgical interns, residents, and attendings at the fictional Seattle Grace Hospital (later renamed Seattle Grace Mercy West Hospital, and finally Grey Sloan Memorial Hospital). The series premiered on March 27, 2005, on ABC as a mid-season replacement and has been renewed annually for two decades. Its title is a mixture of the protagonist's surname and the name of the classic human anatomy textbook Gray's Anatomy. Writer Shonda Rhimes developed the pilot and served as showrunner, head writer, and executive producer until stepping down in 2015. Set in Seattle, Washington, the series is filmed primarily in Los Angeles, California, and Vancouver, British Columbia.

The original cast consisted of nine star-billed actors: Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington, and Patrick Dempsey. For most of its run, the series revolves around Dr. Meredith Grey (Pompeo), chronicling her progression from surgical intern to fully-qualified doctor. The cast has undergone major changes throughout the series' run, with only three original members remaining by the 19th season – Pompeo, Wilson, and Pickens. Pompeo stepped back from the series in its 19th season, at which point the show shifted to more of an ensemble format. In March 2026, ABC renewed the series for a 23rd season. Grey's Anatomy had two spin-off series: Private Practice (2007–2013) and Station 19 (2018–2024); as well as a web series, Grey's Anatomy: B-Team.