'Mitochondrial GTP binding elongation factor (Homo Sapiens, GUF1)', is a protein which in humans is encoded by the GUF1 gene. The GUF1 protein plays an important role in maintaining proper mitochondrial function, ensuring accuracy when mitochondrial genes are being translated. The gene shows the most expression in the brain, while the least expression is found in the pancreas.
This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
via MyGene.info
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'Mitochondrial GTP binding elongation factor (Homo Sapiens, GUF1)', is a protein which in humans is encoded by the GUF1 gene. The GUF1 protein plays an important role in maintaining proper mitochondrial function, ensuring accuracy when mitochondrial genes are being translated. The gene shows the most expression in the brain, while the least expression is found in the pancreas.
== Function and biochemistry == GUF1 is a GTPase that hydrolyzes GTP to GDP and plays an important role in maintaining mitochondrial function by ensuring accurate translation of mitochondrial genes. It helps prevent amino acid mis-incorporation under stress by facilitating ribosomal back-translocation during protein synthesis. Additionally, its C-terminal region aids in tRNA interaction, distinguishing it from other GTPases.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).