half maximal inhibitory concentration
Sign in to saveAlso known as IC50, Inhibitory Concentration 50
thumb|Graphical representation of the IC50 determination of the inhibition of an enzyme's activity by a small molecule ("drug"). Four different concentrations of the small molecule (ranging from 30 to 300 μM) were tested.
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Vinony's link graph records 658 inbound references to half maximal inhibitory concentration, and connects out to antagonist, ligand and signaling receptor.
It sits within the topics Concentration indicators and Pharmacodynamics.
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Research
8,222 papers- Calculating Half Maximal Inhibitory Concentration (IC(50)) Values from Glycomics Microarray Data Using GraphPad Prism.Methods in molecular biology (Clifton, N.J.) · 2022
- Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor.Methods in molecular biology (Clifton, N.J.) · 2020
- Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action.Virulence · 2018
- Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective, and Potent Allosteric TYK2 Inhibitor.The Journal of investigative dermatology · 2026
- Assessing Drug Sensitivity in Fission Yeast Using Half-Maximal Inhibitory Concentration (IC50) Assays.Methods in molecular biology (Clifton, N.J.) · 2025
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Wikidata facts
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Encyclopedic overview
7 sectionsContents
- Functional antagonist assay
- IC<sub>50</sub> and affinity
- Competition binding assays
- Cheng–Prusoff equation
- See also
- References
- External links
thumb|Graphical representation of the IC50 determination of the inhibition of an enzyme's activity by a small molecule ("drug"). Four different concentrations of the small molecule (ranging from 30 to 300 μM) were tested.
Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. The biological component could be an enzyme, cell, cell receptor or microbe. IC50 values are typically expressed as molar concentration.
Excerpted from Wikipedia’s “half maximal inhibitory concentration” article, available under the CC BY-SA 4.0 licence.