HIRA
Sign in to saveAlso known as DGCR1, TUP1, TUPLE1, histone cell cycle regulator
Protein HIRA is a protein that in humans is encoded by the HIRA gene. This gene is mapped to 22q11.21, centromeric to COMT.
Gene data
HIRA- Name
- histone cell cycle regulator
- Type
- protein-coding
- Position
- 19,330,693–19,447,450 (−)
- Aliases
- DGCR1, TUP1, TUPLE1
- Ensembl
- ENSG00000100084
- RefSeq RNA
- NM_003325.4
- RefSeq protein
- NP_003316.3
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
histone cell cycle regulator
- Symbol
- HIRA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:19,330,185-19,447,450
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein HIRA PDB 2i32.png
Show 6 more facts
- HomoloGene ID
- 48172
- exact match
- identifiers.org/ncbigene/7290
- genomic start
- 19318221
- genomic end
- 19435224
- cytogenetic location
- 22q11.21
- Commons category
- HIRA
Sources (3)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Protein HIRA is a protein that in humans is encoded by the HIRA gene. This gene is mapped to 22q11.21, centromeric to COMT.
== Function ==