H2BC12

Also known as H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k, H2B clustered histone 12, HIST1H2BK

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to H2BC12, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Vinony links it to 5 Wikipedia language editions.

Gene data

H2BC12

Name: H2B clustered histone 12
Type: protein-coding
Position: 27,135,928–27,146,863 (−)
Aliases: H2B/S, H2BFAiii, H2BFT, H2BK, HIST1H2BK
Ensembl: ENSG00000197903
RefSeq RNA: NM_001312653.2, NM_080593.2, XR_007059350.1
RefSeq protein: NP_001299582.1, NP_542160.1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015].

Pathways

Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine

via MyGene.info

Gene · Ensembl

H2B clustered histone 12

Symbol: H2BC12
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:27,135,928-27,146,863
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

exact match: identifiers.org/ncbigene/85236
cytogenetic location: 6p22.1
HomoloGene ID: 135980
found in taxon: Homo sapiens
chromosome: human chromosome 6
genomic start: 27146361
genomic end: 27146855
expressed in: fallopian tube

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

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Contents

Interactions
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Further reading

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.

Excerpted from Wikipedia’s “H2BC12” article, available under the CC BY-SA 4.0 licence.