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hydrogen bond

form of association between an electronegative atom and a hydrogen atom attached to a second, relatively electronegative atom

AI overview

A hydrogen bond is a weak attraction that forms between a hydrogen atom (attached to an electronegative atom like oxygen or nitrogen) and another electronegative atom nearby. These bonds are important because they influence how molecules interact with each other, affecting properties like the boiling point of water and the structure of proteins.

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Research

140,805 papers

Hydrogen-Bond Donors in Drug Design.ReviewJournal of medicinal chemistry · 2022Kenny PWDOI: 10.1021/acs.jmedchem.2c01147
Muon disrupts AKT hydrogen bond network in cancer.ReviewJournal of cellular physiology · 2019Radisavljevic ZDOI: 10.1002/jcp.27554
Dynamic hydrogen-bond networks in bacterial protein secretion.ReviewFEMS microbiology letters · 2018Karathanou K, Bondar ANDOI: 10.1093/femsle/fny124
Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones.Molecules (Basel, Switzerland) · 2023Liu H, Liu H, Wang E et al.DOI: 10.3390/molecules28052304
Organo-Polyoxometalate-Based Hydrogen-Bond Catalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Vilona D, Lelli M, Dumont E et al.DOI: 10.1002/chem.202102807
Quantification of Hydrogen-Bond-Donating Ability of Biologically Relevant Compounds.The Journal of organic chemistry · 2024Berlin CB, Sharma E, Kozlowski MCDOI: 10.1021/acs.joc.3c02939
Asymmetric catalysis by chiral hydrogen-bond donors.ReviewAngewandte Chemie (International ed. in English) · 2006Taylor MS, Jacobsen ENDOI: 10.1002/anie.200503132
Molecular tailoring approach as tool for revealing resonance-assisted hydrogen bond: Case study of Z-pyrrolylenones with the NH⋯OС intramolecular hydrogen bond.ReviewJournal of computational chemistry · 2022Afonin AV, Rusinska-Roszak DDOI: 10.1002/jcc.26960

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Wikidata facts

Image: H-Bruecke-delta.svg

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Commons category: Hydrogen bonding

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Article

Model of hydrogen bonds (1) between molecules of water AFM image of naphthalenetetracarboxylic diimide molecules on silver-terminated silicon, interacting via hydrogen bonding, taken at 77 K. ("Hydrogen bonds" in the top image are exaggerated by artifacts of the imaging technique.)

In chemistry, a hydrogen bond (H-bond) is a specific type of molecular interaction that exhibits partial covalent character and cannot be described as a purely electrostatic force. It occurs when a hydrogen (H) atom, covalently bonded to a more electronegative donor atom or group (Dn), interacts with another electronegative atom bearing a lone pair of electrons—the hydrogen bond acceptor (Ac). Unlike simple dipole–dipole interactions, hydrogen bonding arises from charge transfer (nB → σ*AH), orbital interactions, and quantum mechanical delocalization, making it a resonance-assisted interaction rather than a mere electrostatic attraction.