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Structure via PubChem · Public domain (PubChem)
iguratimod
Sign in to saveIguratimod is an anti-inflammatory small molecule drug used for the treatment of rheumatoid arthritis, together with methotrexate in Japan and China. As of 2015, the biological target was not known, but it prevents NF-κB activation and subsequently selectively inhibits COX-2 and several inflammatory cytokines.
Chemical data
- Formula
- C17H14N2O6S
- Molecular weight
- 374.4 g/mol
- IUPAC name
- N-[7-(methanesulfonamido)-4-oxo-6-phenoxychromen-3-yl]formamide
- SMILES
- CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
- InChIKey
- ANMATWQYLIFGOK-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 119 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Sjogren syndrome, lupus nephritis, rheumatoid arthritis, autoimmune thrombocytopenic purpura
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 374.057
Show 2 more facts
- chemical formula
- C₁₇H₁₄N₂O₆S
- canonical SMILES
- CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Iguratimod is an anti-inflammatory small molecule drug used for the treatment of rheumatoid arthritis, together with methotrexate in Japan and China. As of 2015, the biological target was not known, but it prevents NF-κB activation and subsequently selectively inhibits COX-2 and several inflammatory cytokines.
Adverse effects include elevated transaminases, nausea, vomiting, stomach pain, rashes, and itchiness.
Excerpted from Wikipedia’s “iguratimod” article, available under the CC BY-SA 4.0 licence.