insulinoma
Sign in to saveAlso known as Insulin-Producing tumor of Islet cells, Islet cell adenoma (morphologic abnormality), Islet cell adenoma, beta cell tumor of the pancreas, Insulin-Producing Islet Cell Tumor, Pancreatic Insulin Producing Tumor, Beta Cell Tumor, pancreatic insulin-producing tumor
An insulinoma is a tumour of the pancreas that is derived from beta cells and secretes insulin. It is a rare form of a neuroendocrine tumour. Most insulinomas are benign in that they grow exclusively at their origin within the pancreas, but a minority metastasize. Insulinomas are one of the functional pancreatic neuroendocrine tumour (PNET) group ("functional" because it increases production of insulin). In the Medical Subject Headings classification, insulinoma is the only subtype of "islet cell adenoma".
Key facts
- Medical condition (new).name
- Insulinoma
- Medical condition (new).image
- Pancreatic insulinoma (2).JPG
- Medical condition (new).caption
- Pathology of pancreatic endocrine tumour (insulinoma).
- Medical condition (new).field
- Oncology
via Wikipedia infobox
Research
9,108 papers- Approach to the Patient: Insulinoma.The Journal of clinical endocrinology and metabolism · 2024
- Diagnosis and management of insulinoma.World journal of gastroenterology · 2013
- Insulinoma.Neuroendocrinology · 2004
- Ectopic insulinoma: a systematic review.Reviews in endocrine & metabolic disorders · 2023
- Insulinoma in pregnancy.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2010
via PubMed
Wikidata facts
- Image
- Pancreatic insulinoma (2).JPG
Show 3 more facts
- NCI Thesaurus ID
- C3140
- Commons category
- Insulinoma
- exact match
- www.orpha.net/ORDO/Orphanet_97279
via Wikidata · CC0
~4 min read
Article
14 sectionsContents
- Signs and symptoms
- Diagnosis
- Blood tests
- Suppression tests
- Diagnostic imaging
- Treatment
- Prognosis
- Incidence
- History
- Additional images
- See also
- References
- Further reading
- External links
An insulinoma is a tumour of the pancreas that is derived from beta cells and secretes insulin. It is a rare form of a neuroendocrine tumour. Most insulinomas are benign in that they grow exclusively at their origin within the pancreas, but a minority metastasize. Insulinomas are one of the functional pancreatic neuroendocrine tumour (PNET) group ("functional" because it increases production of insulin). In the Medical Subject Headings classification, insulinoma is the only subtype of "islet cell adenoma".
Beta cells secrete insulin in response to increases in blood glucose. The resulting increase in insulin acts to lower blood glucose back to normal levels, the point at which further secretion of insulin is stopped. In contrast, the secretion of insulin by insulinomas is rather independent of blood glucose; these tumours continue to secrete insulin, causing blood glucose levels to fall further below normal.