IQGAP1
Sign in to saveAlso known as HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.
Gene data
IQGAP1- Name
- IQ motif containing GTPase activating protein 1
- Type
- protein-coding
- Position
- 90,388,207–90,502,239 (+)
- Aliases
- HUMORFA01, SAR1, p195
- Ensembl
- ENSG00000140575
- RefSeq RNA
- NM_003870.4, XM_047433204.1, XM_054379044.1
- RefSeq protein
- NP_003861.1, XP_047289160.1, XP_054235019.1
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
IQ motif containing GTPase activating protein 1
- Symbol
- IQGAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:90,388,207-90,502,239
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~13 min read
Encyclopedic overview
15 sectionsContents
- History
- Expression
- Domains
- Related Proteins
- Function
- Interactions
- Function as a Scaffold
- Key pathways
- ERK MAPK
- Cytoskeletal control (actin dynamics)
- Adhesion
- Transcription
- Clinical significance
- References
- Further reading
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.
==History== IQGAP1 was discovered in 1994. Its name stems from the fact that its RasGAP-related domain (GRD) has sequence homology to the Sar1 GTPase. It was hypothesized that IQGAP1 would act as a GTPase activating protein (GAP) protein, promoting the switch of ras GTPases from the active GTP to GDP-bound forms. However, despite the homology of IQGAP’s GAP domain to sar1 and the fact that IQGAP1 binds Rho GTPases Rac1 and Cdc42, IQGAP does not actually have GAP function. Instead, it binds the active (GTP-bound) forms of RAC1 and CDC42 with higher affinity than GDP-bound forms, and stabilizes the active form in vivo.
Excerpted from Wikipedia’s “IQGAP1” article, available under the CC BY-SA 4.0 licence.